Int J Clin Exp Pathol. Disseminated superficial actinic porokeratosis (DSAP) prevalence is not precisely known, although DSAP is the most common form of porokeratosis. Current therapeutic modalities include topical agents, systemic medications, and surgical interventions that have variable efficacy. Treatment of disseminated superficial actinic porokeratosis (DSAP) is poorly standardized. It usually includes using different types of creams and taking oral drugs to hasten the healing process. Thank you for that. But there are rare occurrences of a similar ridge appearing alongside other kinds of skin lesions, so your doctor may perform a biopsyto rule out other diagnoses. If you have a porokeratosis, you are strongly advised to visit your doctor regularly to watch for any signs of skin cancer or worsening of the condition. Remove duct tape and re-evaluate, if you still feel pain or discomfort wait 48 hours and repeat. I have never heard this term till now when I saw your post, so I admit to knowing nothing about this but can give you some ideas to try, to plot a course to carry out between you and your doctor. if(typeof ez_ad_units!='undefined'){ez_ad_units.push([[250,250],'foot_pain_explained_com-medrectangle-4','ezslot_7',177,'0','0'])};__ez_fad_position('div-gpt-ad-foot_pain_explained_com-medrectangle-4-0');Porokeratosis is a general term to a group of dermatological problems that occur in various parts of the body. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Disseminated superficial porokeratosis. Pictures and symptoms of the red, scaly rash. Porokeratosis Ptychotropica is a highly-infrequent skin condition that is typically observed in middle-aged adults (mean age 47 years). FOIA In terms of appearance, DSAP is more extensive than other subtypes and appears as reddish and brown spots. An estimated 7.5 to 11 percent of people with porokeratosis go on to develop a cancerous growth. These lesions are generally not associated with any bony prominence as is the case with a callus or an intractable plantar keratoma. I was ashamed to go into public. Photo Source: www.researchgate.net, Picture 4: Typical signs and symptoms of punctate porokeratotic keratoderma. DOI: Guss SB, et al. DTD is a rare genetic condition that causes short stature and unusually short limbs. . Content may not be reproduced in any form. and transmitted securely. Additionally, the condition may cause more irritation over time. Here is a suggestio. Arthrogryposis is a congenital condition present at birth characterized by a stiffening of the joints. Porokeratosis of Mibelli. Linear porokeratosis of the foot with dermoscopic manifestations: A case report. The extent of malignancy is also considered. (10). Yang J, Du YQ, Fang XY, Li B, Xi ZQ, Feng WL. Porokeratosis and cutaneous malignancy. Learn the types, treatments, and more. It works by removing the surface layer of the skin. Int J Dermatol. Disseminated superficial actinic porokeratosis. Pediatrics. Topical imiquimod cream stimulates a local immune response in the skin, leading to destruction of the actinic keratosis cells. There is a 3% risk that a person with DSAP will develop skin cancer. I have mostly the red irritated spots that contain lumps of keratin--some are linear and some are round with raised edges; those raised edges also contain keratin. Schaller M, Korting HC, Kollmann M, Kind P. Dermatology. Instead, your condition may continue to worsen. Keller LP, Halim K, Abedi SM, Liu W, Gottesman SP. I have porokeratosis. All rights reserved. Observational studies involve recording changes over time among a specific group of people . Current treatment options in Background: Disseminated superficial actinic porokeratosis (DSAP) is a rare dermatologic disorder of the epidermis. When going out in the sun, make sure you wear sunscreen or wear long sleeves. Since then, several variations have been identified. Cryotherapy is the most common treatment. Many successful modalities have only been reported anecdotally in individual cases. If you notice patches of brown bumps that appear to grow and spread, talk to your doctor. In many people they are a non-issue but in others they can be very painful. However, theories as to what causes porokeratosis include: A person with porokeratosis should consider limiting their sun exposure and regularly moisturizing the affected areas. Porokeratosis is a group of uncommon skin conditions in which there is abnormal keratinization 1. Porokeratosis spots often have a rough, raised border that may look like ringworm. Perrin's Blend is a simple, all natural, antioxidant, grape seed extract ointment for Actinic Keratosis and other skin growths. Treatment of porokeratosis. You have an unusually clear, informative and well-written website for laypersons. What happens if you get lots of sun, say several hours per day? As in other clonal keratinocyte disorders, treatment for porokeratosis is primarily focused on lesion destruction by using cryotherapy, photodynamic therapy, carbon dioxide lasers, 5-fluorouracil, or a combination of these therapies. DOI: Teixeira VB, et al. First, I want to let you know that you have the best web site I've found related to foot issues. If you wish to have the lesions removed, your doctor may recommend: Theres no magic bullet for improving porokeratosis lesions in the short term. A porokeratosis lesion in a patient with disseminated superficial actinic porokeratosis. Your doctor will look for a specific feature of this skin plaque, a corned lamella, to confirm the diagnosis. 90, 91 Table 4 summarizes the different topical, systemic, and physical treatment . Bookshelf appreciate it. Disseminated superficial actinic porokeratosis (DSAP) is a non-contagious skin condition with apparent genetic origin in the SART3 gene. Unable to load your collection due to an error, Unable to load your delegates due to an error. 3. All types of porokeratosis except PP come with a risk of developing a cancerous growth in a lesion, usually a squamous cell carcinoma. Thanks for a most interesting website, which has helped a lot. People with DTD have many health complications related to their. Sometimes, these may spread to the extremities and torso. These are the most common courses of treatment for porokeratosis: Topical 5-fluorouracil - improves the symptoms and induces remission of all forms of porokeratosis. arrow-right-small-blue Are you still free of it. A few types of meds can treat blocked sweat glands. Analogues of D3 vitamin - these are administered as topical treatments as well, being especially recommended for the disseminated superficial actinic porokeratosis. The patient says it has increased in size since it was debrided by another DPM. Sucralose side effects: All You Need To Know. Disseminated superficial actinic porokeratosis, or DSAP, is an inherited keratinisation disorder that causes discrete dry patches on the arms and legs. Similar to porokeratosis of Mibelli, this condition appears as patches of brown, scaly spots. As the condition worsens, it can feel dry, itchy, and irritated. Arch Dermatol. These often develop on the torso, arms, or legs. .I have been told that it is not hard enough to be cut off. Disseminated superficial actinic porokeratosis. Porokeratosis: A review of unique group of keratinizing disorder. Mibelli porokeratosis appears as discolored raised skin bumps with a thin border. We're extending 15% off all skincare products! Can diet help improve depression symptoms? The name porokeratosis means scaly pore and is a misnomer as porokeratosis is not related to pores. Surgical modalities other than excision may improve cosmesis and/or . Learn about the underlying causes and, Burns are categorized into different types, depending on severity. Natural Treatments for Porokeratosis? (This might involve "off-label use", which is allowed! It contains a variety of acids including acetic acid which works by sloughing off debris on the skin leaving smoother skin. Topics AZ There is currently no cure for porokeratosis, but several treatments are available that help reduce the appearance of the bumps or lesions. Porokeratosis is a disorder of keratinization that presents with keratotic papules or annular plaques with a well-defined ridge-like border 2. Application of Vitamin E oil or creams or Vitamin D-3 may provide some benefit. There is a high possibility of developing skin cancer. These lesions are thought to be nothing more than plugged sweat glands however there is some debate as to whether this is true or not. Epidermodysplasia Verruciformis: What Is It and How Is It Treated? This discussion is limited to punctate porokeratosis. There are treatment options to help. American Osteopathic College of Dermatology. rarediseases.info.nih.gov/diseases/10983/disseminated-superficial-actinic-porokeratosis, jamanetwork.com/journals/jamadermatology/article-abstract/532436, dermnetnz.org/topics/linear-porokeratosis, dermnetnz.org/topics/porokeratosis-of-mibelli, dermnetnz.org/topics/disseminated-superficial-actinic-porokeratosis/, rarediseases.info.nih.gov/diseases/4438/porokeratosis-of-mibelli, rarediseases.info.nih.gov/diseases/8180/punctate-porokeratosis. So, the obvious questions to ask are:1. Early diagnosis and treatment can prevent skin cancer, Lichenification refers to the skin becoming hard and bumpy in response to repeated rubbing or scratching. (4, 5) Tea tree oil - It is effective in the treatment of actinic keratosis. People that met me thought that is was a communicable disease. A variety of factors may cause DSAP to develop. When the inflammation is difficult to control, chronic eczema can lead to: Hyperkeratosis. The thinner the person the greater the positive impa, One of the best ways to help yourself heal faster after surgery is to eat well. Locations. Objective: Porokeratosis of Mibelli Tacalcitol exerts its biological activity by preventing the proliferation of keratinocytes. Surgical interventions and cryotherapy may be preferred in areas where the use of topical agents is difficult or contraindicated. However, the appearance may improve with the following measures: Sun protectionis important as exposure toultraviolet radiationmay result in the development of askin cancerwithin the linear porokeratosis. 2003 Nov;44(4):281-3. doi: 10.1046/j.1440-0960.2003.00010.x. Porokeratosis is an uncommon diagnosis that presents with keratotic papules or annular plaques with an elevated border. American Osteopathic College of Dermatology: DISSEMINATED SUPERFICIAL ACTINIC POROKERATOSIS., Genetic and Rare Diseases Information Center: Porokeratosis of Mibelli., Indian Dermatology Online Journal: Porokeratosis - Head to toe: An unusual presentation., The MalaCards human disease database: Porokeratosis (DSAP).. It can even turn into skin cancer, with 8% of patients suffering from the . People describe the discomfort as if there were several pebbles stuck to the bottom of their foot or in their shoe. Ramakrishnan R, Vignesh TA, Durai PCT, Narasimhan M. J Family Med Prim Care. However, it can only be done based on the assessment of a health care provider. Read on to find out more about porokeratosis, including its diagnosis, treatment, and causes. She has had a succession of podiatrists call it . Porokeratosis: Present concepts. These reddened, raised plaques on the surface of the skin can be diagnosed as porokeratosis via a biopsy examined under the microscope. Porokeratosis is a rare skin disorder affecting fewer than 200,000 Americans. Cryosurgery and photodynamic therapy are also treatment options, although they offered varying results. Porokeratosis of gluteal region: A case report. Other forms of treatment for porokeratosis plantaris include the use of, These lesions may also be injected. Your doctor may suggest monitoring its growth over time. Porokeratosis plantaris discreta (porokeratosis) is a seed-like hyperkeratotic lesion which may be found on the soles. This method carries the risk of permanent loss of pigment, especially on Black or brown skin. Adverse events did not seem to be any better or wors. A rare case of disseminated superficial porokeratosis-Case report. This characteristic border is called the "cornoid lamella" and is best seen with a microscope or . Heart failure: Could a low sodium diet sometimes do more harm than good? Scot's disseminated superficial actinic porokeratosis began to heal. Estimated Primary Completion Date : October 31, 2021. I have used small cotton round that women use to remove make up as they are flat and inexpensivecut a small square the size of areaand put a few drops of the ACV or Oil on the small square. Apply virgin coconut oil once a day. (2012). Because of a lack of treatment standards for PK, European and international guidelines cannot be created. Thank. Thank you for responding. Prune belly syndrome is a rare congenital condition that affects the abdominal muscles, the abdomen's appearance, and other systems in the body. Punctate porokeratosis is a skin condition that appears in adulthood as many, tiny, ridgelike bumps on the palms of the hands and soles of the feet. Dermatology. Type in 'porokeratosis' in the Search box at the top, and note it responds even before hitting Enter with a dropdown box of many suggested sub-names and topics! BTW, if you're not Caucasian you will have a much harder time getting enough D3 made through sun skin action, even if in southern latitudes nearer the Equator and even if between 10 AM-2 PM! Have started using Apple Cider Vinegar with mother but have not seen any improvement. All rights reserved. , Porokeratosis of Mibelli. Porokeratosis of Mibelli in transplant recipients. Disseminated superficial actinic porokeratosis (DSAP) is a very common form of porokeratosis. 2022 Feb 15;15(2):56-62. eCollection 2022. An article revealing that older type 2 diabetics have a higher incidence of cancer then non-diabetics. Youre at a greater risk for skin cancer with larger patches of porokeratosis mibelli and infections that last longer. It doesn't always work on raised, thicker growths. To the PubMed site, part of NIH, part of HHS:http://www.ncbi.nlm.nih.gov/pubmed. Board-certified dermatologist who specializes in cosmetic, laser, and medical dermatology . 8 Other strategies to reduce scale and inflammation associated with these lesions include acitretin, . 2005 - 2023 WebMD LLC. Because of supply chain shortages as well as staffing shortages particularly during the pandemic, many institutions extended the time between dressing changes for chronic wounds. (2010). Bubna, A. K. (2015). The biopsy should include the raised edge of the lesion. It is a skin condition characterized by reddish brown scaly spots. I used to work for a podiatrist (front desk) back during summers in By Marc Mitnick DPM 2006-2022, foot-pain-explained.com LLC, Researchers are suggesting that the effectiveness of Vitamin D in fighting and preventing disease is predicated on a persons body mass index (BMI). DSAP may be itchy, leading to bleeding from scratching. Porokeratosis. Federal government websites often end in .gov or .mil. All rights reserved. Porokeratosis of Mibelli is a skin condition that usually develops in children or young adults. DOI: Torres T, et al. How much different can the body's metabolism be among the different isomers of D3? Thank you. Is the ketogenic diet right for autoimmune conditions? Porokeratosis of Mibelli showed the best outcomes after treatment with imiquimod cream and linear PK responded well to topical or systemic retinoids. The lesions are usually pink to brownish-red in color. There is no known cure for linear porokeratosis, and treatment generally produces disappointing results. There is a risk that cancerous cells may develop, and these healthcare professionals can regularly monitor the affected areas to check for this outcome. 3200 Downwood Circle, NW Suite 210. By accessing or using this website, you agree to abide by the Medical Disclaimer, Terms of Service, Privacy Policy, and Affiliate Disclosure. Over the years, your porokeratosis may expand to cover more of your skin. DSP is one of the rarer subtypes of porokeratosis and tends to manifest in childhood. In benign cases, your doctor will monitor the lesions and watch for signs of malignancy. EASILY and QUICKLY! You take them by mouth or rub them on your skin. One of the common types of porokeratosis is Porokeratosis of Mibelli. Mibelli porokeratosis is the second most common subtype of porokeratosis, and it typically develops in children or young adults. Am J Med Genet. The raised ring is usually red, and the center of the spot is either the same color as your flesh or slightly paler. 2006Sep;45(9):10779. In most cases, porokeratosis is not a cause for concern. Posted by Andy (Brooklyn, NY) on 03/03/2021. to thank you for an EXCELLENT website. Note that this may not provide an exact translation in all languages, Home Porokeratosis plantaris, palmaris, et disseminate A third type of porokeratosis [abstract]. Learn about causes, possible symptoms, complications, and more. What Causes a Swollen Eyelid, and How Is It Treated? Cortisone injections are usually of no value but. However, whereas DSAP appears only in sun-exposed areas, DSP can also affect areas of the body that do not get exposure to the sun. The present review seeks to comprehensively discuss the potential for laser and light modalities in the treatment of DSAP. Health care professionals strongly believed that porokeratosis is a genetic condition. From my experience, you can use it as little as once per day for about 3 or 4 weeks to reach maximum benefit. Unauthorized use of these marks is strictly prohibited. Would like to know what other people have used with success. (4, 5). If that helps at all, it is very very slow. Looking up one of the Searches yields this one:www.ncbi.nlm.nih.gov/pubmed/10071323. There is no known cure for porokeratosis and treatment is generally disappointing. DOI: What causes porokeratosis and whos at risk? The condition occurs most often in light-skinned adults in their thirties or forties and appears in at least 6 distinct sub-types. Porokeratosis is a specific disorder of keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked, parakeratotic cells extending through the stratum corneum with a thin or absent granular layer. Shrestha S, Aryal R, Homagain S, Tiwari SB, Rayamajhi B, Parajuli S, Paudel U. SAGE Open Med Case Rep. 2022 Nov 28;10:2050313X221139559. autoimmune and inflammatory diseases, including. Porokeratosis are very similar to intractable plantar keratosis, however, the cause of porokeratosis have yet to be determined. We're putting our Laser Center in the spotlight this month and offering 20% off all laser packages, except for the powerhouse CO2 laser, which is 15% off. . Current treatment options in 1974Apr;109(4):5268. Posted by Andy (Brooklyn, NY) on 03/03/2021. Content may not be reproduced in any form. DOI: Ngan V. (2003). Porokeratosis is not contagious, and although it may develop in multiple places, it is unlikely to spread from one part of the body to another through contact. Image Source: img.medscapestatic.com, Image 3: A patient demonstrating the symptoms of linear porokeratosis. I'd try either apple cider vinegar (ACV) or Castor oil. Freezing the growth. And your site is so intelligently arranged. What is the latest research on the form of cancer Jimmy Carter has? DSAP is often misdiagnosed as a rash or other skin lesion, and patients may undergo inappropriate treatment without the correct diagnosis, which is detrimental given the small risk of progression to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and rarely melanoma. Sasson M, Krain AD. Punctate porokeratosis palmaris et plantaris. college years ago, so I know the benefits of good care. By accessing or using this website, you agree to abide by our Medical Disclaimer, Terms of Service, and Privacy Policy agreements. Factors that may exacerbate the pain include: For this reason there are various treatments ranging from absolutely nothing to surgical excision. A distinctiveclinical variant of porokeratosis of Mibelli. About Us · Contact Us · Disclaimer · Privacy and Cookie Policy. HHS Vulnerability Disclosure, Help It consists of a keratinization disorder, which may appear in several clinical forms and can undergo malignant . site (top of google search) and actually find all the answers I needed DSP is similar to DSAP, and they share the same appearance. Thepathologyof porokeratosisis very distinct, but it may be necessary to point out the clinical features for the pathologist to find a cornoid lamella within the pathological specimen. (8). . Although the condition is usually benign, a small number of people may develop skin cancer within a lesion. We avoid using tertiary references. At first, you may notice a small patch of brown bumps. 1996 Apr;22(4):33942. The pathology of porokeratosis is very distinct, but it may be necessary to point out the clinical features for the pathologist to find a cornoid lamella within the pathological specimen. Sunlight, UV rays, and other radiation worsen the condition. Unfortunately, I use my fingernails for lack of a better method. There are many options for the treatment of disseminated superficial actinic porokeratosis. Learn. Multiple clinical variants of porokeratosis exist. You can learn more about how we ensure our content is accurate and current by reading our. In some types of porokeratosis, a family history is present, consistent with a genetic predisposition [3]. arrow-right-small-blue Dermatology Made Easybook. Small Mosaic Wart Laser Removal Treatments, Most Effective Laser Nail Fungus Treatment, Understanding Lasers and Laser Treatments, Laser Spider Vein Removal Treatment Packages, Laser Scar Reduction and Skin Rejuvenation. In 2021, the market is growing at a steady rate and with . An official website of the United States government. Lavender oil - Apply lavender oil twice a day to clear up the spots on the skin. It is a must to protect the skin from extreme heat of the sun so as to prevent the possibility of having skin cancer. Would you like email updates of new search results? . In addition to limiting direct sun exposure, you should always wear sunscreen with an SPF of 30. There are six main subtypes of porokeratosis, which vary in color, size, and where they appear on the body. (2, 3). Porokeratosis is usually diagnosed by its appearance. Porokeratosis can become very painful over time depending on the location. Porokeratosis is a rare, acquired or inherited disorder of keratinization characterized by one or more atrophic macules or patches, each surrounded by a distinctive hyperkeratotic, ridge-like border called a "cornoid lamella" ( picture 1A-B) [ 1,2 ]. It was so great to get to your The same creams that work on porokeratosis of Mibelli also work on DSAP. Truly, it is uncommonly kind. A person should also consider consulting their doctor if they experience any pain, itching, discoloration, or bleeding around the affected sites. The two most common types of this skin condition are porokeratosis of Mibelli and disseminated superficial actinic porokeratosis (DSAP). Regards, DermNet provides Google Translate, a free machine translation service. All rights reserved. The skin lesions that result are dry and atrophic, with a well-defined ridge-like hyperkeratotic border called a cornoid lamella (best seen on dermoscopy) [1]. Sertznig P, et al. THANKS FOR A WONDERFUL AND VERY HELPFUL SITE! Eczema is also called dermatitis. Since Porokeratosis is a result of excess keratinization I have been trying to use a topical UREA cream 40% (known to break down keratin) I got the idea because many people swear by this cream for keratosis pilaris and as a callus remover. (2003). In benign cases, your doctor will monitor the lesions and watch for signs of malignancy. Minimal relief is achieved from this type of debridement. Did you get good results with this cream? Theres also evidence that laser treatments have improved the appearance of porokeratosis. Place the mixture in your refrigerator and leave it for around 3 days until the vinegar has darkened meaning it is ready for use. document.getElementById("ak_js_1").setAttribute("value",(new Date()).getTime()); HealthFixit.com is for informational purposes only and is not a substitute for medical advice or information. Surgical treatment is essential for porokeratosis lesions that have undergone malignant transformation. A dermatologist will inspect the affected areas and possibly perform dermoscopy. DOI: Lanka P, et al. DSAP is caused by an ultra-sensitivity to sunlight. Here is what the various D3 isomers look like, including tacalcitol:http://www.uspharmacist.com/CMSImagesContent/2009/7/USP0907-Consult-F2.gif. It also affects the face, shoulders, neck, and even the genitals. J Dermatol. We performed a systematic literature search in an electronic database for published literature. (5, 6), There is a variety of treatment options for porokeratosis. Last medically reviewed on January 13, 2021, A look at hyperkeratosis, a condition where the skin becomes thicker than normal. Hello how are you, I would like to find out if there is a natural treatment for porokeratosis? The patient was a 35-year-old man, who complained of pruritic papules and plaques in the perianal and buttock region for thirteen years. Please note that we use cookies necessary for the functioning of our website, cookies that optimize the performance. Punctate porokeratosis is a very rare subtype of porokeratosis. 10 Many of the traditional therapies used for PM had previously been used in our patient, . After treatment, the skin will feel raw and sore. "Successful treatment of porokeratosis of Mibelli with diamond fraise dermabrasion". Often misdiagnosed as chronic UV-damage or actinic keratoses, patients are treated for years with different therapeutic options with little success. It is more frequently seen in women, probably because they more readily seek advice for cosmetic concerns. It is important to limit sun and UV exposure to the affected areas of your skin. Other possible causes or porokeratosis are weakened immune system, excessive exposure to ultraviolet rays of the sun, radiation, and side effects of therapeutic phototherapy. What you can do to improve your condition? Included is detail on types of hyperkeratosis and when to see a, Actinic keratosis is a precancerous skin condition that causes patches of rough, patchy lesions. Linear porokeratosis. it usually appears in adulthood, starts on the palms of the hands and soles of the feet and gradually spreads over the skin. Disseminated superficial actinic porokeratosis. A systematic review of light and laser treatment modalities was conducted to include 26 cases of patients with DSAP. So far this seems to be working but it is very slowMy lesions are on my calves and thighs. Aug 2011 - Present11 years 8 months. The https:// ensures that you are connecting to the 2005-2023 Healthline Media a Red Ventures Company. Disseminated superficial porokeratosis in a patient with cholangiocarcinoma: A paraneoplastic manifestation? MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The spots covered entirely my legs and arms, such that . It is sometimes confused with actinic keratosis which is also caused by sun exposure (See Patient Information Leaflet on Actinic Keratoses ); however, actinic keratosis is . eCollection 2022 Jul. Before Do chronic wounds need to be dressed daily? Porokeratosis is associated with mevalonate pathway gene mutations. Individuals with this condition often develop other . Just dab a bit of apple cider vinegar directly on the . Unfortunately, there is no cure for Disseminated Superficial Actinic Porokeratosis. LP and PPPD begin on palms and soles but can spread elsewhere. Porokeratosis is most commonly found among children and young adults. Your doctor may also do a biopsy if it looks like a lesion may have a cancerous growth. Their size, onset and distribution depends on the specific type of porokeratosis. Porokeratosis is the general term for a group of skin conditions causing small, discolored bumps with a raised border to appear on the skin. Dip a cotton ball or swab into the mix and apply it to the affected areas several times each day. Picture Source: img.medscapestatic.com, Photo 2: A patient suffering from disseminated superficial actinic porokeratosis. By this time, a patient seeking treatment for a "porokeratosis" or "IPK" is frustrated and is "doctor shopping." Her history and physical exam show that she has had the 2 mm diameter lesion for six months. Topical vitamin D acid derivatives may be the best therapeutic option for disseminated PK. There is no known cure for DSAP and porokeratosis of Mibelli, but creams such as topical retinoids, 5-fluorouracil and imiquimod offer some slight help. Topical creams, gels and solutions are prescribed for use in patients with numerous or widespread actinic keratoses. Important Disclaimer: The information contained on Healthy Focus is intended for informational and educational purposes only.
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